I was able to apply this serum under makeup without any issue. The makeup adheres to my skin just as well as with any other primers, and there was no residue. However, I generally prefer wearing serums at night, as it feels a bit heavy for daytime wear. This one, in particular, would feel too thick for daytime, in my opinion. A couple of our editors like applying it in the morning, though, so it could come down to personal preference.